A metabolomics-based molecular pathway analysis of how the sodium-glucose co-transporter-2 inhibitor dapagliflozin may slow kidney function decline in patients with diabetes.
Skander Tahar MulderAnn HammarstedtSunil B NagarajViji NairWenjun JuJonatan HedbergPeter J GreasleyJan W ErikssonJan OscarssonHiddo J Lambers HeerspinkPublished in: Diabetes, obesity & metabolism (2020)
The observed molecular pathways targeted by dapagliflozin and associated with DKD suggest that modifying molecular processes related to energy metabolism, mitochondrial function and endothelial function may contribute to its renal protective effect.