Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes.

Kei AdachiShin-Ichi MiyajimaNobuhisa NakamuraMegumi MiyabeYasuko KobayashiToru NishikawaYuki SuzukiTakeshi KikuchiShuichiro KobayashiTomokazu SaikiMakoto MizutaniNorikazu OhnoToshihide NoguchiAkio MitaniTatsuaki MatsubaraKeiko Naruse

Published in: Journal of clinical periodontology (2017)

These results indicate the involvement of PARP activation in the pathogenesis and aggravation of periodontal disease in diabetes and suggest the therapeutic potential of PARP inhibition for treating periodontal disease, especially in patients with diabetes.

Keyphrases

type diabetes
cardiovascular disease
dna damage
glycemic control
dna repair
oxidative stress
adipose tissue
skeletal muscle