Comparison of ultra-performance liquid chromatography and ARK immunoassay for therapeutic drug monitoring of voriconazole.

Diego Peña-LorenzoNoemi RebolloJosé Germán Sánchez-HernándezAranzazu Zarzuelo-Castañeda

Published in: Annals of clinical biochemistry (2021)

Although both techniques can be used for TDM of voriconazole, when a value close to the lower limit of the therapeutic range is determined by the ARKTM immunoassay, it would be better to verify the result by a non-automated technique to avoid possible underdosing.

Keyphrases

liquid chromatography
mass spectrometry
sensitive detection
machine learning
high resolution mass spectrometry
high resolution
deep learning
high throughput
tandem mass spectrometry
label free
solid phase extraction
gas chromatography