Ticagrelor Prevents Endothelial Cell Apoptosis through the Adenosine Signalling Pathway in the Early Stages of Hypoxia.
Catherine FeliuHélène PeyretSylvie Brassart-PascoFloriane OszustGaël PoitevinPhilippe NguyenHervé MillartZoubir DjeradaPublished in: Biomolecules (2020)
we described an endothelial cytoprotective mechanism of ticagrelor against hypoxia stress, independent of blood elements. We highlighted a mechanism triggered mainly by the increased extracellular bioavailability of adenosine, which activates A2B and A3 receptors on the endothelium.
Keyphrases
- endothelial cells
- acute coronary syndrome
- percutaneous coronary intervention
- st elevation myocardial infarction
- antiplatelet therapy
- st segment elevation myocardial infarction
- high glucose
- oxidative stress
- nitric oxide
- protein kinase
- vascular endothelial growth factor
- endoplasmic reticulum stress
- cell death
- cell cycle arrest
- mouse model