Obesity and Breast Cancer Risk in Men: A National Case-Control Study in England and Wales.

Anthony J Swerdlow Cydney L BruceRosie CookePenny CoulsonJames GriffinAlison ButlinBeverley SmithM Jill SwerdlowMichael E Jones

Published in: JNCI cancer spectrum (2021)

Obesity at all adult ages, particularly recent abdominal obesity, is associated with raised risk of breast cancer in men, probably because of the conversion of testosterone to estrogen by aromatase in adipose tissue. The association is particularly strong for HER2-expressing tumors.

Keyphrases

insulin resistance
metabolic syndrome
adipose tissue
weight loss
breast cancer risk
high fat diet induced
type diabetes
weight gain
high fat diet
skeletal muscle
middle aged
quality improvement
replacement therapy
estrogen receptor
wild type