Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice.
Hendrik J P van der ZandeJoost M LambooijVivien ChavanelleAnna Zawistowska-DeniziakYolanda OteroFrank OttoLouise LantierOwen P McGuinnessFlorian Le JoubiouxMartin A GieraThierry MaugardSébastien L PeltierPascal SirventBruno GuigasPublished in: International journal of obesity (2005) (2021)
Our results show that Totum-63 reduces inflammation and improves insulin sensitivity and glucose homeostasis in obese mice through pleiotropic effects on various metabolic organs. Altogether, plant-derived Totum-63 might constitute a promising novel nutritional supplement for alleviating metabolic dysfunctions in obese people with or without T2D.