Peroxisome proliferator-activated receptor γ activation ameliorates liver fibrosis-differential action of transcription factor EB and autophagy on hepatocytes and stellate cells.

Yunjin J YumJin YooKyuhoon BangJi Eun JunIn-Kyung JeongKyu Jeung AhnHo Yeon ChungYou Cheol Hwang

Published in: Hepatology communications (2023)

Activation of PPARγ with RGZ ameliorated liver fibrosis and downregulation of TFEB and autophagy in HSCs may be important for the antifibrotic effects of PPARγ activation.

Keyphrases

liver fibrosis
transcription factor
cell death
induced apoptosis
signaling pathway
endoplasmic reticulum stress
insulin resistance
oxidative stress
cell cycle arrest
skeletal muscle
type diabetes
metabolic syndrome
cell proliferation
binding protein