Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars.

Shihui YangAli MohagheghiMary Ann FrandenYat-Chen ChouXiaowen ChenNancy DoweMichael E HimmelMin Zhang

Published in: Biotechnology for biofuels (2016)

This study confirms the value of integrating bioinformatics analysis and systems biology data during metabolic engineering endeavors, provides guidance for value-added chemical production in Z. mobilis, and reveals the interactions between host metabolism, oxygen levels, and a heterologous 2,3-BDO biosynthesis pathway. Taken together, this work provides guidance for future metabolic engineering efforts aimed at boosting 2,3-BDO titer anaerobically.

Keyphrases

bioinformatics analysis
electronic health record
wastewater treatment
quality improvement
big data
machine learning
deep learning
cell wall
saccharomyces cerevisiae