IL-8 and PI3K pathway influence the susceptibility of TRAIL-sensitive colorectal cancer cells to TRAIL-induced cell death.

Kelly Xue Jing JongElsa Haniffah Mejia MohamedSaiful Effendi SyafruddinFarid Nazer FaruquKumutha Malar VellasamyKamariah IbrahimZaridatul Aini Ibrahim

Published in: Molecular biology reports (2024)

Collectively, findings from this study identified the role of IL-8 and PI3K in modulating CRC cells' sensitivity to TRAIL. Further validation of these two potential molecular targets is warranted to overcome TRAIL resistance in CRC.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
signaling pathway
high glucose
drug induced
cell proliferation
endothelial cells
climate change