GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity.
Luis I RuffoloKatherine M JacksonPeyton C KuhlersBenjamin S DaleNathania M Figueroa GuillianiNicholas A UllmanPaul R BurchardShuyang S QinPeter G JuvilerJessica Millian KeilsonAshley B MorrisonMary GeorgerRachel JewellLaura M CalviTimothy M NyweningMichael R O'DellAram F HezelLuis De Las CasasGregory B LesinskiJen Jen YehRoberto Hernandez-AlejandroBrian A BeltDavid C LinehanPublished in: Gut (2021)
iCCA uses the GM-CSF-bone marrow axis to establish an immunosuppressive tumour microenvironment. Blockade of the GM-CSF axis promotes antitumour T cell immunity.