Contributing factors in the development of acute lung injury in a murine double hit model.

Philipp StörmannNils BeckerLeander KünnemeyerSebastian WutzlerJan Tilmann VollrathThomas LustenbergerFrank HildebrandIngo MarziBorna Relja

Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2019)

Early observed lung injury with moderate inflammatory changes after blunt chest trauma recovered quickly, and therefore, may be caused by mechanical lung injury. In contrast, lung injury in the ALI group did not undergo recovery and is closely associated with significant changes of inflammatory mediators. This model may be used for further examinations of contributing factors and therapeutic strategies to prevent ALI.

Keyphrases

oxidative stress
magnetic resonance
trauma patients
lipopolysaccharide induced
lps induced
magnetic resonance imaging
contrast enhanced
inflammatory response