Temporal Correlation of CSF and Neuroimaging in the Amyloid-Tau-Neurodegeneration Model of Alzheimer Disease.
Anna H BoerwinkleJulie K WischCharles D ChenBrian A GordonOmar H ButtSuzanne E SchindlerCourtney SutphenShaney FloresAylin DincerTammie L S BenzingerAnne M FaganJohn C MorrisBeau M AncesPublished in: Neurology (2021)
CSF Aβ42 and PiB PET best agree when acquired in close temporal proximity, whereas CSF phosphorylated tau precedes flortaucipir PET by 4 to 8 years. CSF and neuroimaging measures of neurodegeneration have low correspondence and are not interchangeable at any time interval.