Islet Transplantation Reverses Podocyte Injury in Diabetic Nephropathy or Induced by High Glucose via Inhibiting RhoA/ROCK/NF-κB Signaling Pathway.
Chongchu HuangYi ZhouHongjian HuangYushu ZhengLijun KongHewei ZhangYan ZhangHongwei WangMei YangXiaona XuBicheng ChenPublished in: Journal of diabetes research (2021)
Islet transplantation can reverse podocyte injury in diabetes nephropathy by inhibiting the RhoA/ROCK1 signaling pathway. Islet cells have a strong protective effect on podocytes treated with high glucose (35.0 mmol/L glucose). Discovery of signaling pathways affecting podocyte recovery is helpful for individualized efficacy evaluation and targeted therapy of islet transplantation patients.
Keyphrases
- high glucose
- signaling pathway
- induced apoptosis
- endothelial cells
- diabetic nephropathy
- pi k akt
- cell cycle arrest
- epithelial mesenchymal transition
- end stage renal disease
- newly diagnosed
- type diabetes
- chronic kidney disease
- cell therapy
- ejection fraction
- peritoneal dialysis
- cell proliferation
- metabolic syndrome
- blood glucose
- inflammatory response
- cell death
- glycemic control
- weight loss
- lps induced
- nuclear factor