Immune cell subsets in interface cutaneous immune-related adverse events associated with anti-PD-1 therapy resemble acute graft versus host disease more than lichen planus.

Guillermo E Almodovar Cruz Genevieve Kaunitz Julie E Stein Inbal B Sander Travis Hollmann Tricia R Cottrell Janis M Taube Joel C Sunshine

Published in: Journal of cutaneous pathology (2022)

The composition of immune cell subsets in anti-PD-1 interface cirAEs more closely resembles the immune response seen in aGVHD than LP within our cohort. This warrants a closer look via advanced analytics and may have implications for shared pathogenesis and potential treatment options.

Keyphrases

immune response
peripheral blood
liver failure
big data
respiratory failure
drug induced
aortic dissection
dendritic cells
hepatitis b virus
extracorporeal membrane oxygenation
cell therapy
climate change
acute respiratory distress syndrome
replacement therapy