Inter-organellar nucleic acid communication by a mitochondrial tRNA regulates nuclear metabolic transcription.
Christopher RouyaKing Faisal YambireMark L DerbyshireHanan AlwaseemSohail F TavazoiePublished in: bioRxiv : the preprint server for biology (2023)
Multiple mitochondrial-derived tRNAs are detected in human cell nucleiMtAsn promotes binding between NARS2 and HDAC2Metabolic alterations driven by mtAsn impact cell proliferationMtAsn inhibition releases HDAC2 to bind and transcriptionally regulate multiple nuclear genes.