Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function.

Katarzyna KluskaManuel D Peris-DíazDawid PłonkaAlexander Moysa Michał Dadlez Aurélien DeniaudWojciech BalArtur Krężel

Published in: Chemical communications (Cambridge, England) (2020)

Silver (Ag(i)) binding to consensus zinc fingers (ZFs) causes Zn(ii) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(i)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

Keyphrases

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