In vitro evolution of cefepime/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy.

Isabel BarcelóGabriel CabotSnehal PalwePrashant JoshiSwapna TakalkarHariharan PeriasamySara Cortés-LaraLaura ZamoranoIrina Sánchez-DienerBartolome Moya Sachin S BhagwatMahesh PatelAntonio Oliver

Published in: The Journal of antimicrobial chemotherapy (2021)

Development of cefepime/zidebactam resistance in P. aeruginosa required multiple simultaneous mutations that were associated with a significant impairment of fitness and virulence.

Keyphrases

pseudomonas aeruginosa
body composition
physical activity
biofilm formation
cystic fibrosis
escherichia coli
staphylococcus aureus
acinetobacter baumannii
antimicrobial resistance
drug resistant
multidrug resistant