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Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology.

Izhac NazyUlrich J SachsDonald M ArnoldSteven E McKenziePhil ChoiKarina AlthausMaria Therese AhlénRuchika SharmaRachael F F GraceTamam Bakchoul
Published in: Journal of thrombosis and haemostasis : JTH (2021)
Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.
Keyphrases
  • high glucose
  • diabetic rats
  • coronavirus disease
  • sars cov
  • healthcare
  • clinical practice
  • drug induced
  • mental health
  • venous thromboembolism
  • endothelial cells
  • stress induced
  • adverse drug