Predictive value of immunological markers after bacille Calmette-Guérin induction in bladder cancer.

Amr A ElsawyHassan Abol-EneinMahmoud LaymonAsmaa E AhmedAhmed EssamEman T HamamAbdel-Aziz A ZidanMohamed H ZahranAhmed A ShokeirAmira Awadalla

Published in: BJU international (2021)

Urinary IL-10 and serum TNF-α can significantly predict ICR. Moreover, change pattern of urinary IL-10, serum CTLA-4, TFs (GATA3, T-bet and FoxP3) and GATA3+ /T-bet+ ratio after BCG induction can independently predict further BCG response. These markers could be implemented in clinical practice when management options are discussed or in systems with severe BCG shortage.

Keyphrases

clinical practice
transcription factor
regulatory t cells
rheumatoid arthritis
muscle invasive bladder cancer
immune response
dendritic cells