Immune-Mobilizing Monoclonal T Cell Receptors Mediate Specific and Rapid Elimination of Hepatitis B-Infected Cells.

Joannah R Fergusson Zoë WallaceMary M ConnollyAmanda P WoonRichard J SucklingDominic W HineClaire BarberWilawan BunjobpolBeak-San ChoiSara CrespilloMarcin DembekNele DieckmannJose DonosoLuis F GodinhoTressan GrantDawn Howe Michelle L McCullyCarole PerotAnshuk SarkarFlorian U SeifertPraveen K SinghKerstin A StegmannBethany TurnerAnil VermaAndrew WalkerSarah LeonardMala K MainiKatrin WiederholdLucy DorrellRuth Simmons Andrew Knox

Published in: Hepatology (Baltimore, Md.) (2021)

The ImmTAV platform has the potential to enable the elimination of infected cells by redirecting endogenous non-HBV-specific T cells, bypassing exhausted HBV-specific T cells. This represents a promising therapeutic option in the treatment of chronic hepatitis B, with our lead candidate now entering trials.

Keyphrases

hepatitis b virus
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death
signaling pathway
high throughput
multiple myeloma
climate change
human health