Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients.
Pooja-Shree MishraDinesh K DhullA NaliniK VijayalakshmiT N SathyaprabhaPhalguni Anand AlladiTrichur R RajuPublished in: Journal of neuroinflammation (2016)
Our study demonstrates that the astroglial cells contribute to the neuroinflammation-mediated neurodegeneration in the in vitro model of sporadic ALS.
Keyphrases
- amyotrophic lateral sclerosis
- end stage renal disease
- cerebrospinal fluid
- newly diagnosed
- ejection fraction
- induced apoptosis
- chronic kidney disease
- traumatic brain injury
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- late onset
- signaling pathway
- cell death
- lps induced
- inflammatory response
- endoplasmic reticulum stress
- cerebral ischemia
- blood brain barrier
- subarachnoid hemorrhage