Single-cell RNA sequencing reveals diverse B cell phenotypes in patients with anti-NMDAR encephalitis.

Sisi LiXiang HuMinjin WangLuoting YuQi ZhangJing XiaoZhen HongDong ZhouJin-Mei Li

Published in: Psychiatry and clinical neurosciences (2023)

B cell subpopulations in the CSF and PB of NMDAR-E patients exhibit distinct compositions and transcriptomic features. In vitro, non-DN cells from NMDAR-E can differentiate into DN cells and ASCs, potentially producing NR1-IgG antibodies. Further research is necessary to investigate the potential contribution of DN cell subpopulations to NR1-IgG antibody production. This article is protected by copyright. All rights reserved.

Keyphrases

single cell
rna seq
end stage renal disease
high throughput
induced apoptosis
newly diagnosed
ejection fraction
chronic kidney disease
heavy metals
cell cycle arrest
stem cells
cell death
peritoneal dialysis
oxidative stress
cell therapy
bone marrow
endoplasmic reticulum stress