Comparing methods for fetal fraction determination and quality control of NIPT samples.
Daphne M van BeekRoy StraverMarian M WeissElles M J BoonKarin Huijsdens-van AmsterdamCees B M OudejansMarcel J T ReindersErik A SistermansPublished in: Prenatal diagnosis (2017)
We recommend the use of a combination of methods to prevent the issue of reports on samples with insufficient fetal DNA; SANEFALCON to check for presence of fetal DNA, SeqFF for estimating the fetal fraction for a female pregnancy and any Y-based method for estimating the fetal fraction for a male pregnancy. © 2017 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.