Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms.
Mariana Barreto SerraWermerson Assunção BarrosoCláudia Quintino da RochaPablo G R FurtadoAntonio Carlos Romão BorgesSelma do Nascimento SilvaMarcelo M P TangerinaJessyane R do NascimentoWagner VilegasAdemilton C AlvesDenise F BarbeiroHeraldo P de SouzaIracelle C AbreuMarilene Oliveira da Rocha BorgesPublished in: Evidence-based complementary and alternative medicine : eCAM (2020)
Ten compounds were identified in the extract, distributed among the classes of flavonoids and triterpenes. Treatment with FtEHJ increased the wound contraction in 24 hours, such as reduction of TNF-α, IL-1β, and IL-6 (pg/mL) cytokines in the lesion. The TGF-β and collagen gene expression was increased and the wound closure accelerated to nine days, with discrete inflammation, collagenization, and accented reepithelialization. Conclusions. The results obtained suggest chemical compounds present in the FtEHJ accelerates wound healing by being a gene expression modulator, and protein content of different molecules are involved in tissue repair.