SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats.

Chenghua ZhouYufeng ZhangXiaowei JiaoGuizhi WangRuiyao WangYu-Qing Wu

Published in: Regional anesthesia and pain medicine (2020)

These results suggest that, by deacetylating FoxO3a and further reducing its phosphorylation, ubiquitination and degradation in the spinal dorsal horn, SIRT3 stabilizes FoxO3a protein and inhibits oxidative stress, resulting in pain alleviation in T2DM model rats.

Keyphrases

neuropathic pain
spinal cord
oxidative stress
spinal cord injury
transcription factor
signaling pathway
pi k akt
ischemia reperfusion injury
type diabetes
dna damage
induced apoptosis
adipose tissue
wound healing
mouse model
protein kinase
metabolic syndrome
weight loss
endoplasmic reticulum stress
amino acid