We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense interest in the inherited alleles associated with the development of CH. DNA variants near TERT, SMC4, KPNA4, IL12A, CD164, and ATM confer the strongest associations. In this review, we discuss our current state of knowledge regarding germline predisposition to CH.
Keyphrases
- room temperature
- dna repair
- healthcare
- mental health
- cardiovascular disease
- public health
- dna damage
- oxidative stress
- body composition
- copy number
- single molecule
- circulating tumor
- cell free
- type diabetes
- young adults
- dna damage response
- gene expression
- metabolic syndrome
- dna methylation
- hematopoietic stem cell
- health promotion