The Significance of Thiol/Disulfide Homeostasis and Ischemia-modified Albumin Levels in Assessing Oxidative Stress in Obese Children and Adolescents

Eda Mengen Ucakturk Seyit Ahmet Uçaktürk Pınar Kocaay Ozlem Kaymaz Salim Neşelioğlu Ozcan Erel

Published in: Journal of clinical research in pediatric endocrinology (2019)

Chronic inflammation due to oxidative stress induced by impaired metabolic parameters in MUO children caused impairment in thiol redox homeostasis. Our data suggested that the degree of oxidant imbalance in obese children worsened as obesity and metabolic abnormalities increased. It is hypothesized that thiol/disulfide homeostasis and high serum IMA levels may be reliable indicators of oxidant-antioxidant status in MUO children.

Keyphrases

oxidative stress
weight loss
young adults
metabolic syndrome
type diabetes
adipose tissue
anti inflammatory
insulin resistance
bariatric surgery
obese patients
physical activity
skeletal muscle
induced apoptosis
endoplasmic reticulum stress
data analysis