Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia.

Eunyoung LeeXilin ZhangTomoe NodaJunki MiyamotoIkuo KimuraTomoaki TanakaKenichi SakuraiRyo HatanoTakashi Miki

Published in: International journal of molecular sciences (2021)

α-CD elicits its anti-hyperglycemic effect after glucose loading by inducing lecithin inclusion in the gut lumen and activating SREBP2, which is known to induce cholecystokinin secretion to suppress hepatic glucose production via a gut/brain/liver axis.

Keyphrases

blood glucose
signaling pathway
mouse model
white matter
type diabetes
multiple sclerosis
oxidative stress
subarachnoid hemorrhage
glycemic control
insulin resistance
diabetic rats