Amiodarone exacerbates brain injuries after hypoxic-ischemic insult in mice.
Masakazu KotodaSohei HishiyamaTadahiko IshiyamaKazuha MitsuiTakashi MatsukawaPublished in: BMC neuroscience (2019)
Amiodarone exacerbated brain injuries and neurological outcomes after hypoxic-ischemic insults. Severe brain sodium accumulation and brain edema were associated with the detrimental effects of amiodarone. Amiodarone at the clinical dose can exacerbate brain injury after hypoxic-ischemic insult by affecting sodium ion transportation and facilitate intracellular sodium accumulation in the brain.