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A phylogenomic analysis of Limosilactobacillus reuteri reveals ancient and stable evolutionary relationships with rodents and birds and zoonotic transmission to humans.

Fuyong LiXudong LiChristopher C ChengDalimil BujdošStephanie TollenaarDavid J SimpsonGuergana TassevaMaria Elisa Perez-MuñozSteven FreseMichael G GänzleJens WalterJinshui Zheng
Published in: BMC biology (2023)
Overall, this study demonstrates that the evolutionary relationship of a vertebrate gut symbiont can be stable in particular hosts over time scales that allow major adaptations and specialization, but also emphasizes the diversity of symbiont lifestyles even within a single bacterial species. For L. reuteri, symbiont lifestyles ranged from autochthonous, likely based on vertical transmission and stably aligned to rodents and birds over evolutionary time, to allochthonous possibly reliant on zoonotic transmission in humans. Such information contributes to our ability to use these microbes in microbial-based therapeutics.
Keyphrases
  • genome wide
  • microbial community
  • small molecule
  • dna methylation
  • healthcare
  • health information
  • high intensity