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Stiffness regulates the proliferation and osteogenic/odontogenic differentiation of human dental pulp stem cells via the WNT signalling pathway.

Nanxin LiuMi ZhouQi ZhangTao ZhangTaoran TianQuanquan MaChangyue XueShiyu LinXiaoxiao Cai
Published in: Cell proliferation (2018)
Our results showed that mechanical factors can regulate the proliferation and differentiation of DPSCs via the WNT signalling pathway. This provides theoretical basis to optimize dental or bone tissue regeneration through increasing stiffness of extracelluar matrix.
Keyphrases
  • stem cells
  • signaling pathway
  • endothelial cells
  • mesenchymal stem cells
  • cell proliferation
  • bone marrow
  • bone mineral density
  • oral health
  • bone loss