The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study.
Xīn GàoYan ZhangBarbara BurwinkelYang XuanBernd HolleczekHermann BrennerBen SchöttkerPublished in: Clinical epigenetics (2019)
The finding for ALOXE3 may not be causal. As ALOXE3 is mainly expressed in skin tissue, the observed association might reflect the fact that both DNA methylation at the ALOXE3 gene and urinary 8-isoprostane concentrations depend on the level of OS in tissues. Contrarily, the finding for the MTOR gene and breast cancer is biologically plausible because the MTOR protein plays an important role in PI3K/Akt signaling, which is a pathway related to cancer development and cell senescence.
Keyphrases
- dna methylation
- genome wide
- pi k akt
- cell proliferation
- papillary thyroid
- oxidative stress
- signaling pathway
- gene expression
- copy number
- squamous cell
- risk factors
- dna damage
- cell cycle arrest
- childhood cancer
- single cell
- type diabetes
- cardiovascular events
- squamous cell carcinoma
- soft tissue
- skeletal muscle
- ischemia reperfusion injury
- bone marrow
- protein protein
- stress induced
- small molecule
- mesenchymal stem cells
- binding protein
- diabetic rats
- drug induced