Armochaetoglasins J and K: new cytochalasans from Chaetomium globosum.

Li ChengXi ZhengQin LiMeng-Sha WeiChun-Mei ChenHu-Cheng ZhuChang-Li ZengXin-Cai HaoYong-Hui Zhang

Published in: Natural product research (2021)

Two novel cytochalasans, armochaetoglasin J (1) and armochaetoglasin K (2), along with 14 known analogues (3-16) were isolated from Chaetomium globosum. Their structures were elucidated by HRESIMS, NMR spectroscopy, single-crystal X-ray crystallography, and ECD spectra. Armochaetoglasins J and K were found to be inactive against the HepG2, HT-29, K562, HL-60, and A549 cancer cell lines.

Keyphrases

high resolution
papillary thyroid
squamous cell
dual energy
computed tomography
magnetic resonance imaging
mass spectrometry
magnetic resonance
childhood cancer