Factors affecting lymphocyte collection efficiency for the manufacture of chimeric antigen receptor T cells in adults with B-cell malignancies.

Sherilyn A TuazonAng LiTheodore GooleyThomas W EunsonDavid G MaloneyCameron J TurtleMichael L LinenbergerLaura S Connelly-Smith

Published in: Transfusion (2019)

Lymphocyte collection at our center was well tolerated and 100% successful in manufacturing CD19-directed CAR T cells from adult patients with B-cell malignancies despite low CE in some patients. A diagnosis of ALL, advancing age, and higher preapheresis platelet counts were observed to be associated with low CE.

Keyphrases

end stage renal disease
peripheral blood
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
energy transfer