Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.

Tyler D HitchmanGabriella BayshtokEmilie Ceraudo Amanda R MooreCindy LeeRuobing JiaNaitao WangMohini R PachaiAlexander N Shoushtari Jasmine H FrancisYouxin GuanJuliet ChenMatthew T ChangBarry S TaylorThomas P SakmarThomas HuberPing Chi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data suggest that the combination of Gαq and MEK inhibition provides a promising therapeutic strategy and improved therapeutic window of broadly targeting Gαq in uveal melanoma.See related commentary by Neelature Sriramareddy and Smalley, p. 1217.

Keyphrases

pi k akt
skin cancer
electronic health record
cancer therapy
drug delivery
machine learning
data analysis