Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Bram P PrinsTimothy J MeadJennifer A BrodyGardar SveinbjornssonIoanna NtallaNathan A BihlmeyerMarten van den BergJette Bork-JensenStefania CappellaniStefan Van DuijvenbodenNikolai T KlenaGeorge C GabrielXiaoqin LiuCagri GulecNiels GrarupJeffrey HaesslerLeanne M HallAnnamaria IorioAaron IsaacsRuifang Li-GaoHonghuang LinChing-Ti LiuLeo-Pekka LyytikäinenJonathan MartenHao MeiMartina Müller-NurasyidMichele OriniSandosh PadmanabhanFarid RadmaneshJulia RamirezAntonietta RobinoMolly SchwartzJessica van SettenAlbert V SmithNiek VerweijHelen R WarrenStefan WeissAlvaro AlonsoDavid O ArnarMichiel L BotsRudolf A de BoerAnna F DominiczakMark EijgelsheimPatrick T EllinorXiuqing GuoStephan B FelixTamara B HarrisCaroline HaywardSusan R HeckbertPaul L HuangJ W JukemaMika KähönenJan A KorsPier D LambiaseLenore J LaunerMan LiAllan LinnebergChristopher P NelsonOluf PedersenMarco PerezAnnette PetersOzren PolasekBruce M PsatyOlli T RaitakariKenneth M RiceJerome I RotterMoritz F SinnerElsayed Z SolimanTim D SpectorKonstantin StrauchUnnur ThorsteinsdottirAndrew TinkerStella TrompetAndré UitterlindenIlonca VaartjesPeter van der MeerUwe VölkerHenry VölzkeMelanie WaldenbergerJames G WilsonZhijun XieFolkert W AsselbergsMarcus DörrCornelia M van DuijnPaolo GaspariniDaniel F GudbjartssonVilmundur GudnasonTorben HansenStefan KääbJørgen K KantersCharles KooperbergTerho LehtimäkiHenry J LinSteven A LubitzDennis O Mook-KanamoriFrancesco J ContiChristopher H Newton-ChehJonathan RosandIgor RudanNilesh J SamaniGianfranco SinagraBlair H SmithHilma HolmBruno H StrickerSheila UliviNona SotoodehniaSuneel S AptePim van der HarstKari StefanssonPatricia B MunroeDan E ArkingCecilia W LoYalda JamshidiPublished in: Genome biology (2018)
Our approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes.