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Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice.

Enjun HeHaitao SuiHongjie WangXiang ZhaoWeihong GuoZhicheng DaiZhenkai WuKai HuangQinghua Zhao
Published in: Stem cell reviews and reports (2024)
To sum up, IL-19 inhibited BMSCs osteogenic differentiation in old mice. Our findings shed novel lights on pathogenic mechanism underlying age-related bone loss and laid a foundation for further research on identifying novel targets to treat senile osteoporosis.
Keyphrases
  • bone loss
  • bone marrow
  • mesenchymal stem cells
  • high fat diet induced
  • postmenopausal women
  • signaling pathway
  • bone mineral density
  • insulin resistance
  • type diabetes
  • metabolic syndrome
  • risk assessment