Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice.

Enjun HeHaitao SuiHongjie WangXiang ZhaoWeihong GuoZhicheng DaiZhenkai WuKai HuangQinghua Zhao

Published in: Stem cell reviews and reports (2024)

To sum up, IL-19 inhibited BMSCs osteogenic differentiation in old mice. Our findings shed novel lights on pathogenic mechanism underlying age-related bone loss and laid a foundation for further research on identifying novel targets to treat senile osteoporosis.

Keyphrases

bone loss
bone marrow
mesenchymal stem cells
high fat diet induced
postmenopausal women
signaling pathway
bone mineral density
insulin resistance
type diabetes
metabolic syndrome
risk assessment