Rhabdomyolysis-Induced AKI Was Ameliorated in NLRP3 KO Mice via Alleviation of Mitochondrial Lipid Peroxidation in Renal Tubular Cells.

Seok Jong SongSu-Mi KimSang-Ho LeeJu-Young MoonHyeon Seok HwangJin Sug KimSeon-Hwa ParkKyung Hwan JeongYang-Gyun Kim

Published in: International journal of molecular sciences (2020)

NLRP3 depletion ameliorated renal tubular injury in a murine glycerol-induced acute kidney injury (AKI) model. A lack of NLRP3 improved tubular cell viability via attenuation of myoglobin-induced mitochondrial injury and lipid peroxidation, which might be the critical factor in protecting the kidney.

Keyphrases

acute kidney injury
high glucose
diabetic rats
endothelial cells
cardiac surgery
oxidative stress
induced apoptosis
drug induced
nlrp inflammasome