Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome.

Xiaoman YuanSiyi HanAnne ManyandeFeng GaoJie WangWen ZhangXue-Bi Tian

Published in: European journal of pain (London, England) (2022)

Our research indicates that the Kv1.3 channel in the spinal cord contributes to neuropathic pain by promoting microglial M1 polarization and activating the NLRP3 inflammasome.

Keyphrases

neuropathic pain
nlrp inflammasome
spinal cord
spinal cord injury
image quality
signaling pathway
dual energy
lipopolysaccharide induced
magnetic resonance imaging
computed tomography
inflammatory response