Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review.
Mahima JoshiJaved MuneerLawrence MbuagbawIpsita R GoswamiPublished in: PloS one (2023)
No multidimensional pain scale has been tested for reliability and construct validity in hypothermic encephalopathic neonates. There is an increasing trend towards using routine sedation/analgesia during TH worldwide. Wide variability in the type of medication used, administration (bolus versus infusion), and dose ranges used emphasizes the urgent need for standardized practice recommendations and guidelines. There is insufficient data on the long-term neurological outcomes of exposure to these medications, adjusted for underlying brain injury and severity of encephalopathy. Future studies will need to develop framework tools to enable precise control of sedation/analgesia drug exposure customized to individual patient needs.
Keyphrases
- brain injury
- pain management
- postoperative pain
- subarachnoid hemorrhage
- clinical practice
- ultrasound guided
- mechanical ventilation
- cerebral ischemia
- chronic pain
- healthcare
- low birth weight
- primary care
- adverse drug
- cardiac arrest
- electronic health record
- current status
- early onset
- case report
- neuropathic pain
- adipose tissue
- type diabetes
- machine learning
- preterm birth
- intensive care unit
- acute respiratory distress syndrome
- big data
- artificial intelligence
- blood brain barrier
- spinal cord
- spinal cord injury
- data analysis
- weight loss
- metabolic syndrome
- deep learning