Genome-wide DNA methylation profiling in ectopic and eutopic of endometrial tissues.

Nadia BarjasteMaryam ShahhoseiniParvaneh AfsharianAli Sharifi-ZarchiAli Masoudi-Nejad

Published in: Journal of assisted reproduction and genetics (2019)

Our results confirmed the role of DNA methylation alternations in endometriosis development and pathogenesis. Our finding suggests aberrant DNA methylation can activate several signaling pathways including PI3k-AKT signaling, relaxin, and oxytocin which are associated with the pathogenesis of endometriosis.

Keyphrases

dna methylation
pi k akt
genome wide
signaling pathway
gene expression
cell proliferation
cell cycle arrest
copy number
induced apoptosis
single cell
cell death
oxidative stress