Active conductive head cooling of normal and infarcted brain: A magnetic resonance spectroscopy imaging study.
William K DiproseCatherine A MorganMichael Tm WangJames P DiproseJoanne C LinSulaiman SheriffDoug CampbellP Alan BarberPublished in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2022)
Active conductive head cooling is a simple and non-invasive intervention that may slow infarct growth in ischemic stroke. We investigated the effect of active conductive head cooling on brain temperature using whole brain echo-planar spectroscopic imaging. A cooling cap (WElkins Temperature Regulation System, 2nd Gen) was used to administer cooling for 80 minutes to healthy volunteers and chronic stroke patients. Whole brain echo-planar spectroscopic imaging scans were obtained before and after cooling. Brain temperature was estimated using the Metabolite Imaging and Data Analysis System software package, which allows voxel-level temperature calculations using the chemical shift difference between metabolite (N-acetylaspartate, creatine, choline) and water resonances. Eleven participants (six healthy volunteers, five post-stroke) underwent 80 ± 5 minutes of cooling. The average temperature of the coolant was 1.3 ± 0.5°C below zero. Significant reductions in brain temperature (ΔT = -0.9 ± 0.7°C, P = 0.002), and to a lesser extent, rectal temperature (ΔT = -0.3 ± 0.1°C, P = 0.03) were observed. Exploratory analysis showed that the occipital lobes had the greatest reduction in temperature (ΔT = -1.5 ± 1.2°C, P = 0.002). Regions of infarction had similar temperature reductions to the contralateral normal brain. Future research could investigate the feasibility of head cooling as a potential neuroprotective strategy in patients being considered for acute stroke therapies.
Keyphrases
- resting state
- white matter
- high resolution
- cerebral ischemia
- data analysis
- functional connectivity
- computed tomography
- magnetic resonance
- heart failure
- mass spectrometry
- magnetic resonance imaging
- multiple sclerosis
- risk assessment
- molecular docking
- acute myocardial infarction
- newly diagnosed
- coronary artery disease
- current status
- brain injury
- prognostic factors
- photodynamic therapy
- peritoneal dialysis
- optical coherence tomography
- human health
- percutaneous coronary intervention