Nesfatin-1 treatment preserves antioxidant status and attenuates renal fibrosis in rats with unilateral ureteral obstruction.
Neslihan TezcanZarife Nigâr Özdemir-KumralNaziye Özkan YenalÖzlem T Çilingir-KayaAysin Tulunay VirlanDilek ÖzbeyliŞule ÇetinelBerrak Ç YeğenMehmet KoçPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)
The present data demonstrate that UUO-induced renal fibrosis is ameliorated by NES-1, which appears to involve the inhibition of neutrophil infiltration and thereby amelioration of oxidative stress and inflammation. These data suggest that NES-1 may have a regulatory role in protecting the kidneys against obstruction-induced renal injury.