Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway.
Min JianJason Shing-Cheong KwanMyriam BuntingRoy Chun-Laam NgKoon Ho ChanPublished in: Journal of neuroinflammation (2019)
Our findings demonstrate that APN inhibits inflammatory response of microglia to AβO via AdipoR1-AMPK-NF-κB signaling, and APN deficiency aggravates microglia activation and neuroinflammation in AD mice. APN may be a novel therapeutic agent for inhibiting neuroinflammation in AD.
Keyphrases
- inflammatory response
- lps induced
- signaling pathway
- lipopolysaccharide induced
- pi k akt
- toll like receptor
- skeletal muscle
- epithelial mesenchymal transition
- induced apoptosis
- high glucose
- metabolic syndrome
- traumatic brain injury
- diabetic rats
- insulin resistance
- high fat diet induced
- protein kinase
- type diabetes
- neuropathic pain
- cognitive impairment
- cell proliferation
- drug induced
- spinal cord
- wild type
- subarachnoid hemorrhage