The Impact of Genetic and Non-Genetic Factors on Warfarin Dose Prediction in MENA Region: A Systematic Review.

Published in: PloS one (2016)

Variants of VKORC1 and CYP2C9 are the strongest predictors of warfarin dose variability among the different populations from MENA. Although many of those populations share the same ancestry and are similar in their warfarin dose predictors, a population specific dosing algorithm is needed for the prospective estimation of warfarin dose.

Keyphrases

atrial fibrillation
direct oral anticoagulants
venous thromboembolism
oral anticoagulants
copy number
genome wide
machine learning
deep learning
gene expression