Mitochondrial metabolic substrate utilization in granulosa cells reflects body mass index and total follicle stimulating hormone dosage in in vitro fertilization patients.
Richard J KordusAkhtar HossainHenry E MalterHolly A LaVoiePublished in: Journal of assisted reproduction and genetics (2020)
Granulosa cell utilization of substrates feeding into the citric acid cycle changed with total FSH dosage and BMI. Fertilization rate, 8-cell embryo quality, and blastocyst formation also associated with different energy substrate usage. Mitochondrial substrate utilization by granulosa cells from individual follicles could be further developed into a useful diagnostic tool.
Keyphrases
- end stage renal disease
- oxidative stress
- single cell
- polycystic ovary syndrome
- cell therapy
- induced apoptosis
- chronic kidney disease
- ejection fraction
- body mass index
- prognostic factors
- peritoneal dialysis
- stem cells
- type diabetes
- cell cycle arrest
- structural basis
- bone marrow
- patient reported outcomes
- mesenchymal stem cells
- cell death
- metabolic syndrome
- cell proliferation
- patient reported