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Bromopyrrole Alkaloids from the Sponge Agelas kosrae.

Oh-Seok KwonDonghwa KimHeegyu KimYeon-Ju LeeHyi-Seung LeeChung J SimDong-Chan OhSang Kook LeeKi-Bong OhJongheon Shin
Published in: Marine drugs (2018)
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.
Keyphrases
  • molecular docking
  • climate change
  • wild type