MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid.
Hyowon HongSae-Bom YoonJung Eun ParkJung In LeeHyun Young KimHye Jin NamHeeyeong ChoPublished in: Annals of clinical and translational neurology (2023)
Our results demonstrate that MeCP2 is required for the expansion of neural progenitor cells by modulating BMP pathway at early stages of development, and this influence persists during neurogenesis and gliogenesis at later stages of brain organoid development.