IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
Arjen H G ClevenJohnny SuijkerGeorgios AgrogiannisInge H Briaire-de BruijnNorma FrizzellAttje S HoekstraPauline M Wijers-KosterAnne-Marie Cleton-JansenJudith V M G BovéePublished in: Clinical sarcoma research (2017)
In summary, in central chondrosarcoma IDH1 or -2 mutations do not affect immunohistochemical levels of 5-hmC, 5mC, trimethylation of H3K4, -K9 and K27 and outcome, as compared to wildtype.