miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure.

Qingxi QuLing-Hong LiuYuqian CuiHongli LiuJingyang YiWeidong BingChunxiao LiuDetian JiangYanwen Bi

Published in: Stem cell research & therapy (2022)

Our findings revealed that hucMSCs-derived exosomes carrying miR-126-3p promote angiogenesis and attenuate OGCs apoptosis in POF, which highlighted the potential of exosomes containing miR-126-3p as an effective therapeutic strategy for POF treatment.

Keyphrases

mesenchymal stem cells
umbilical cord
endothelial cells
cell therapy
bone marrow
vascular endothelial growth factor
oxidative stress
endoplasmic reticulum stress
cell proliferation
cell cycle arrest
stem cells
induced pluripotent stem cells
risk assessment
human health
skeletal muscle
pi k akt